What is e+?  Isagenix e+ is an adaptogen-powered energy shot with plant-based caffeine that delivers immediate and sustained energy. It’s a convenient 2-ounce ready-to-drink energy shot made with natural ingredients to help you fight fatigue and improve mental and physical performance. e+ contains naturally sourced caffeine derived from green tea and yerba maté, along with a proprietary blend of botanical adaptogens to support energy, stamina, and mental alertness.